TNF and Sepsis: Figure 4B and 4C demonstrates that IL-6 and TNF-α levels in ADMSC-EVs treated LPS-induced septic mice were significantly lower than in control groups. Notably, mortality rates were substantially reduced in the ADMSC-EV group compared to control groups, with an 80% mortality rate due to LPS-induced sepsis (Figure 4D). Flow cytometry analyses revealed an increased percentage of F4/80+CD206+ macrophages and F4/80+CD206+IL-10+ macrophages in ADMSC-EVs treated LPS-mediated septic mice (Figure 4E and 4F).