To elucidate the function of H3K18la lactylation in cardiac hypertrophy, we pharmacologically inhibited lactylation using specific inhibitors, oxamate, which is a lactylation inhibitor, through inhibiting the activity of lactate dehydrogenase A. We also evaluated their effects on hypertrophic markers and cardiac function in both TAC and PE‐induced models. Here, LDHA is linked to cardiac hypertrophy.