However, overexpression of GATA4 expression significantly reversed the lactylation inhibition attenuated cardiac hypertrophy in TAC mice, as evidenced by decreased cardiac function (Figures 7A and S4), increased HW/BW and LV/TL ratios (Figure 7B), and normalized cardiomyocyte sizes by H&E (Figure 7C) and WGA (Figure 7D, E) staining of heart sections. Here, GATA4 is linked to cardiac hypertrophy.