Specifically, five upregulated co-expressed genes exhibited significant positive associations with Alzheimer’s disease: METTL7A (OR = 1.067; 95% CI: 1.026–1.110; P = 0.001), SERPINB6 (OR = 1.022; 95% CI: 1.002–1.043; P = 0.033), VASP (OR = 1.046; 95% CI: 1.002–1.092; P = 0.040), ENTPD2 (OR = 1.015; 95% CI: 1.015–1.099; P = 0.007), and CXCL1 (OR = 1.060; 95% CI: 1.019–1.104; P = 0.004). This evidence concerns the gene ENTPD2 and early-onset autosomal dominant Alzheimer disease.