In the training set, the results of univariate analysis showed that the history of atrial fibrillation, valvular heart disease, LVEF, LVEDD, 6 MWT, systolic blood pressure, diastolic blood pressure, heart rate, blood creatinine, urea nitrogen level, and BNP level between the treatment ineffective group (n = 40) and the effective group (n = 135) had statistical differences (P < 0.05). The gene discussed is NPPB; the disease is atrial fibrillation.