PA has been reported to be potentially beneficial for individuals with quiescent IBD.3,27,44 It is been hypothesized that during exercise, interleukin 6 (IL-6) is released from muscles and this exerts an anti-inflammatory effect in those with chronic inflammation, as IL-6 inhibits TNF production and enhance the stimulation of IL-1ra and IL-10.45 The full extent of the benefits of PA is yet to be elucidated as research on this subject is quite sparse. The gene discussed is TNF; the disease is inflammatory bowel disease.