Th cells differentiate into subsets with distinct cytokine profiles: Th1 cells produce IFN‐γ and IL‐2, promoting cytotoxic immunity; Th2 cells secrete IL‐4, IL‐5 and IL‐13, contributing to humoral responses; and Th17 cells generate IL‐17 and IL‐22, which can be either tumor‐promoting or ‐suppressive depending on context.81, 82, 83, 84. The gene discussed is IFNG; the disease is neoplasm.