IL6 and Hyperglycemia: Hussain et al. [19] reported that hyperglycemia could induce the decreased expression of the free radical scavenger superoxide dismutase 1, as well as aldehyde dehydrogenase 2, and promote the inflammatory mediator′s expression such as NF‐κB, interleukin (IL)‐1β, IL‐6, and TNF‐α, ultimately causing the lesions of vascular endothelial cells and smooth muscle cells and contributing to the development of diabetic vasculopathy.