The expression analysis for the 14 potential hub genes was performed, and only 10 hub genes between T2DM samples and Con samples were statistically different (Figure 7a), in which four hub genes (BMP4, MMP2, SNAI2, and LEP) were significantly upregulated and six hub genes (PTK2, FGF13, NT5E, AGT, UBE2V2, and PSMD14) were significantly downregulated. This evidence concerns the gene PTK2 and type 2 diabetes mellitus.