The ROC validation for the 10 hub genes was performed, and nine hub genes showed AUCs > 0.7 with p < 0.05 (including 0.918 for BMP4, 0.818 for PTK2, 0.845 for FGF13, 0.836 for NT5E, 0.809 for AGT, 0.773 for MMP2, 0.864 for LEP, 0.845 for UBE2V2, and 0.773 for PSMD14, respectively) (Figure 8), indicating that the hub genes had a good discrimination for T2DM samples from Con samples. This evidence concerns the gene PSMD14 and type 2 diabetes mellitus.