Mutations in theVCP gene have been implicated in a spectrum of neurodegenerative diseases, including the inclusion body myopathy with Paget’s disease and frontotemporal dementia (IBMPFD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease.5–7 These pathogenic variants disrupt the VCP’s function, leading to impaired protein clearance, mitochondrial dysfunction, and aberrant stress granule dynamics, ultimately contributing to neuronal degeneration. This evidence concerns the gene VCP and amyotrophic lateral sclerosis.