Surgical resection removes the antigen source, precipitating a rapid fall in anti-p53 antibodies; the concurrent relief of mutant-p53-mediated immunosuppression helps restore antitumor immunity, a pattern echoed in NSCLC cohorts where persistently high anti-p53 titers predicted early relapse and shorter survival [32]. This evidence concerns the gene TP53 and non-small cell lung carcinoma.