NOS2 and breast carcinoma: Another study using a 7,12-di-methylbenz(a)anthracene (DMBA)-induced breast cancer model of female rats, highlighted rutin’s impact on inflammatory signaling by downregulating interleukin 6/NF-κB, and modulating SRC1/HSP90, and ER-α signaling pathways, ultimately suppressing tumor biomarkers, including Carcinoma Antigen 15-3, proto-oncogene Tyrosine-Protein Kinase Src1 and Inducible Nitric Oxide Synthase (iNOS) [30].