They used keywords such as “rutin and cancer,” “rutin and inflammation,” “rutin and oxidative stress,” “rutin and angiogenesis,” “rutin and STAT-3,” “rutin and Akt/PI3K,” “rutin and breast cancer,” “rutin and lung cancer,” “rutin and cervix cancer,” “rutin and liver cancer,” “rutin and gastric cancer,” and “rutin and leukemia.” The review also explores the synergistic effects of rutin with other compounds. The gene discussed is AKT1; the disease is cancer.