HES1 and glioblastoma: Given that HES1 oscillations are known to facilitate the transition out of quiescence (Marinopoulou et al., 2021; Sueda et al., 2019), it is plausible to hypothesise that sustained, non-oscillatory SOX2 expression could prevent quiescent glioblastoma cells from reactivating, thereby impairing tumour reactivation and progression.