For instance, HES1 has been shown to oscillate in a proliferative breast cancer model (Sabherwal et al., 2021), Moreover, recent studies have demonstrated that HES1 dynamics changes during the dormancy and reactivation of breast cancer cells, and disruption of these oscillations prevents cell cycle re-entry and induces cell death (Cottrell et al., 2025). The gene discussed is HES1; the disease is breast cancer.