In HCC, epidermal growth factor receptor (EGFR), Met, and other factors induce tyrosine phosphorylation of β-catenin, leading to its dissociation from cell–cell adhesion and and activation, which further promotes its entry into the nucleus to interact with TCF/LEF and influence gene transcription (Figure 2) (4, 9, 11, 23-24). Here, EGFR is linked to hepatocellular carcinoma.