HNF4A and hepatocellular carcinoma: Several small-molecule inhibitors, including PKF115–854 and CGP049090, can block the interaction between β-catenin and TCF, thereby inhibiting HCC growth in vivo (112, 113).To form a transcriptionally active β-catenin/TCF complex, β-catenin recruits transcriptional coactivators, such as cyclic AMP response element-binding protein (CBP), along with other components of the basic transcription machinery.