reported at least five distinct CTNNB1-specific missense mutations: S33P (4/5), D32V (3/5), T41A (2/5), D32G (2/7) and N387 (1/5); these mutations are associated with the classic morphology of β-catenin-mutated HCC (27). The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.