Notably, the reduction of immunosuppressive cytokines, such as TGF-β, in conjunction with potential increases in immunostimulatory signals, can significantly enhance the activity and proliferation of CD8+ cytotoxic T lymphocytes (discussed in Section 3.4) and augment the cytotoxicity of Natural Killer (NK) cells (discussed in Section 3.3), thereby fostering a more robust anti-tumor immune response. This evidence concerns the gene CD8A and neoplasm.