ATP1B2 encodes the β2 subunit of Na+/K+-ATPase, a crucial ion pump that maintains transmembrane electrochemical gradients, facilitates alveolar fluid clearance, and preserves epithelial barrier integrity; Na+/K+-ATPase dysfunction is a recognized mechanism of pulmonary edema in ALI (28, 29). Here, ATP1B2 is linked to acute respiratory distress syndrome.