All children or adults presenting with ALPS-like/CVID-like or IPEX-like phenotype undergo systematic evaluation to detect laboratory pointers indicative of an underlying Tregopathy: cytopenia, eosinophilia in complete blood count, abnormalities in CD3/CD4/CD8/NK/B cell and their subsets, Treg enumeration, immunoglobulin levels to identify hypergammaglobulinemia, especially high IgE and hypogammaglobulinemia. Here, CD8A is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.