IGHE and food allergy: Additionally, atypical mechanisms may mimic such states: in our own recent work, we described neutralizing anti-IL-6 autoantibodies in a patient with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome (57), which likely induced a hyper-IgE-like phenotype with prominent food allergy, despite the absence of overt Th2 skewing.