The IEI genes most frequently implicated in the allergy patients were Dedicator of cytokinesis 8 (DOCK8, 51.2%, n=107), autosomal dominant negative Caspase recruitment domain family member 11 (CARD11 (AD DN), 7.7%, n=16), and then Forkhead box P3 (FOXP3, 5.3%, n=11), Phospholipase C gamma 2 (PLCG2, 5.3%, n=11) and X-linked Wiskott-Aldrich syndrome (WAS (XL), 5.3%, n=11). This evidence concerns the gene CARD11 and allergic disease.