All 11 allergy cases were due to PLCG2 deficiency leading to PLAID (PLCG2 associated antibody deficiency and immune dysregulation), whereas the 31 cases of recurrent fever were observed in other conditions, most notably Familial cold autoinflammatory syndrome 2 caused by NLRP12 variants and Familial Mediterranean fever caused by MEFV variants. Here, PLCG2 is linked to agammaglobulinemia.