On the other hand, the pathophysiology of food-protein induced enterocolitis syndrome (FPIES), a non-IgE, cell-mediated food allergy characterized by delayed onset vomiting and diarrhea and in severe cases, clinically relevant hypotension and marked dehydration (59–61), is suspected to involve antigen-specific T-cell responses and activation of innate immune cells (62). The gene discussed is IGHE; the disease is food allergy.