As an important functional cell subset to maintain body homeostasis, the CD177+ neutrophil population is also closely related to systemic multisystem diseases, including digestive system diseases, respiratory system diseases, reproductive system, immune system, etc.CD177 is directly or indirectly involved in the occurrence and progression of disease by regulating the function of neutrophils, or a small number of CD177 expressed outside neutrophils are directly involved in disease. The gene discussed is CD177; the disease is digestive system disorder.