Anti-CD177 effectively reduces neutrophil infiltration and the release of specific inflammatory cytokines, such as IL-1β, while also diminishing the expression of NLRP3, caspase-1, PAD4, MPO, and ROS, indicating that CD177-mediated NET formation and NLRP3 inflammasome formation are involved in ALI/ARDS, which is consistent with the research of Zhang et al (35). This evidence concerns the gene PADI4 and acute respiratory distress syndrome.