CTLA4 and Sepsis: Although the number of Treg was not altered after sepsis (Supplementary Figure S9J, Figure 6K), a higher number of Treg expressing inhibitory markers was noticed, specifically a higher number of KLRG1+ Treg in CLP compared to SHM animals (Supplementary Figure S9M), and a higher number of PD-1+ and CTLA-4+, but not of KLRG1+ Treg in CLP+STZ compared to SHM+STZ (Figures 6L-N).