A study was carried out in macrophage-derived M1 exosomes where these exosomes were polarized into the M1 phenotype with the aid of M1 enhancers such as NF-KB p50 siRNA, which silences the antiapoptotic activity of NF-KB-P50 in cancer cells, and miR-511-3p (93, 94). This evidence concerns the gene NFKB1 and cancer.