NOTCH1 and lung carcinoma: Then, in the effort to identify the signaling pathway involved in the activation of EMT, levels of Notch 1 and cleaved Notch 1 were tested in untreated and NET-treated lung cancer cells and increased levels of both molecules were found, indicating the central role of Notch 1 in NET-dependent activation of EMT especially in oncogene-driven lung cancer cell lines.