The signaling pathways involved in the activation of EMT in cancer cells exposed to NETs are not completely elucidated but, as reported above, several evidences indicate the involvement of β catenin, certain cytokines, TGFβ, NF-kB, Notch 1 and ITGB1-ILK axis that may act independently or synergistically (Figure 2). Here, NOTCH1 is linked to cancer.