In this case, the diagnosis of autoimmune GFAP astrocytopathy was confirmed based on the following criteria: (i) acute onset with the primary clinical syndrome being meningitis; (ii) exclusion of infectious diseases; (iii) positive detection of GFAP-IgG antibodies in CSF, which serves as a diagnostic biomarker; (iv) good response to corticosteroid therapy; and (v) CSF findings consistent with the current literature. Here, GFAP is linked to meningitis.