Indeed, S. aureus challenge induced increased expression of Defβ14 (Figures 5C, D), RegIIIg (Figures 5G, H), and LCN2 (Figures 5I, J) in both the lungs and trachea, which have been shown to play important roles in S. aureus-induced pneumonia (34–37). Here, DEFB114 is linked to susceptibility to pneumonia measurement.