Conversely, resistant patients showed modest increases in arginine/citrulline/ornithine (p < 0.01), aspartic acid, lysine, and glutamic acid (all p < 0.05), compared to treatment-naïve EGFR- mutated NSCLC patients, although the effect sizes were small (Log2FC < 1.0, Table S8). This evidence concerns the gene EGFR and non-small cell lung carcinoma.