APP and Alzheimer disease: Using APP/PS1 transgenic mouse models and BV2 microglial cell systems, Yu et al. (57) systematically evaluated the effects of nanoplastic exposure on cognitive function and Alzheimer’s disease (AD) pathology, the study demonstrated that exposure to environmentally relevant doses of nanoplastics aggravates cognitive impairment and promotes β-amyloid (Aβ) plaque deposition.