The presence of P1426H, S1576L, H2093Q, and S3319Y variants in the tandem repeat domain of MUC4 can change the mucin interactome under normal and pathological conditions facilitating the interactions of mucins with the surface receptor to initiate oncogenic signaling leading to tumor proliferation, metastasis, and resistance to apoptosis which are characteristics of PDAC (Figure 2). This evidence concerns the gene MUC4 and neoplasm.