Characterized by both motor symptoms (bradykinesia, resting tremor, rigidity, postural instability) and prodromal non-motor symptoms (constipation, cognitive impairment, depression), PD results from the pathogenic loss of dopaminergic neurons in the midbrain (substantia nigra pars compacta) and the toxic accumulation of misfolded alpha-synuclein (αSyn) in Lewy bodies (Bloem et al., 2021; Brás and Outeiro, 2021). The gene discussed is SNCA; the disease is Parkinson disease.