There were no differences in OS or EFS for patients with HLA-identical versus unrelated matched or mismatched donors, primary indication for HSCT (autoimmunity/IPEX-like disease, CID, or severe infections), or STAT1 mutation domain (BDB domain, CCD, or other) (Fig. S5 A). Here, STAT1 is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.