CLIC6 and cancer: The results showed that CLIC6 mRNA expression levels were lower in 11 types of malignant tumor tissues, including BRCA, COAD, ESCA, HNSC, KICH, KIRC, LIHC, LUSC, PRAD, READ, and THCA, compared to their corresponding normal tissues (P < 0.05); however, CLIC6 mRNA expression levels were higher in three types of malignant tumor tissues, including KIRP, LUAD, and PCPG, in comparison to their respective healthy tissues (P < 0.05; Figure 1A).