CLIC6 and cancer: The findings indicate that, compared to normal tissue, in 14 types of malignant tumor tissues, CLIC6 mRNA expression levels are notably reduced, including BLCA, BRCA, COAD, HNSC, KICH, KIRC, LGG, LIHC, LUSC, OV, PRAD, READ, SKCM, and STAD (P < 0.05); however, in 10 types of malignant tumor tissues, CLIC6 mRNA expression levels were notably elevated, including DLBC, ESCA, GBM, KIRP, LAML, LUAD, PAAD, TGCT, THYM, and UCEC (P < 0.05; Figure 1B).