Heatmaps showed that in 14 cancer types, including BRCA, COAD, HNSC, KIRC, LGG, LIHC, LUSC, PAAD, PCPG, PRAD, READ, SARC, SKCM, and UVM, CLIC6 mRNA expression levels were positively correlated with the infiltration levels of most TIICs, with some TIICs exhibiting a significant positive correlation between their infiltration levels and CLIC6 mRNA expression levels. Here, CLIC6 is linked to cancer.