However, in multivariate Cox regression adjusting for clinical covariates including age, gender, and TNM stage, the association between PLOD expression and survival was no longer significant (PLOD1: p = 0.888; PLOD2: p = 0.416; PLOD3: p = 0.736), while advanced tumor stage (HR = 2.164, p < 0.001) and age (p < 0.001) remained independent prognostic factors (Supplementary Figure S4B). This evidence concerns the gene PLOD1 and neoplasm.