Using 8 matched ccRCC/normal tissue pairs (6 T1b and 2 T2 stage; 7 Fuhrman grade 2 and 1 grade 3), we confirmed significant PLOD upregulation at both mRNA (Figures 2A, D) and protein levels (Figures 2B, C, E, F; Supplementary Figure S3) in tumor samples compared to normal controls. The gene discussed is PLOD1; the disease is nonpapillary renal cell carcinoma.