This study is a retrospective analysis of our case series and literature review of aggressive B-cell lymphomas with MYC rearrangements that show immunophenotypic immaturity, including expression of terminal deoxynucleotidyl transferase (TdT), weak or negative CD20, and the absence of surface membrane immunoglobulin (smIg) and light chains. This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.