We gathered case reports and series of aggressive B-cell lymphomas (including DLBCL, HGBCL, Burkitt lymphoma, mantle cell lymphoma, and B-lymphoblastic lymphoma) from PubMed that showed MYC rearrangement through FISH or G-banding, and displayed unusual immature B-cell features like TdT positivity on immunohistochemistry, CD20 negativity, or loss of flow cytometric smIg. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.