The overexpression of GPX4 was observed in several cancers, including adrenocortical carcinoma (ACC), COAD, diffuse large B-cell lymphoma (DLBC), ESCA, glioblastoma multiforme (GBM), HNSC, kidney chromophobe (KICH), KIRC, KIRP, brain lower grade glioma (LGG), LIHC, LUAD, lung squamous cell carcinoma (LUSC), ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), PRAD, READ, SARC, skin cutaneous melanoma (SKCM), STAD, THCA, thymoma (THYM), UCEC, and uterine carcinosarcoma (UCS). The gene discussed is GPX4; the disease is cutaneous melanoma.