Using immunohistochemistry and immunofluorescence, we analyzed the expression of PD-L1 and CD163 in clinical GC samples and found that the degree of infiltration of M2-TAMs may be related to clinicopathological features: the greater the degree of pathological differentiation and malignancy, the greater the number of M2-TAMs in the GC microenvironment. This evidence concerns the gene CD274 and gastric cancer.