Relatively low numbers of CD4+ T cells and CD8+ T cells have also been observed in all three types of CIN (34).Other studies have shown that as the grade of CIN increases, the CD4+ T cell level decreases, while the CD8+ T cell level increases (35).In contrast, our data showed that with the upgrading of CIN, the local vaginal levels of CD4+ T cells and CD8+ T cells also increased. Here, CD8A is linked to cervical squamous intraepithelial neoplasia.