CD8A and cervical squamous intraepithelial neoplasia: Some studies suggest that IL-10 is an immunosuppressive factor that promotes the occurrence of CIN or cervical cancer (15),while others consider it (11) an anti-tumor factor that inhibits the proliferation of cancer cells (16).IL-10 can increase the activation of CD8+ T cells (17).Persistent high-risk HPV infection means the immune system fails to clear the virus.