As a result, high-risk HPV infection persists, inducing the accumulation of ineffective CD4+ T cells and CD8+ T cells in CIN, so CIN persists or progresses (8, 36, 37).Our previous research (14) found that the decrease in local vaginal IL-2 levels increases the risk of CIN. The gene discussed is CD4; the disease is cervical squamous intraepithelial neoplasia.