After considering all potential confoundering factors, those with local vaginal CD4 ≤6.65 pg/ml (median) were 34% (OR = 0.34,95% CI: 0.13,0.94) of the risk of CIN in those with CD4>6.65 pg/ml; CD8 ≤ 6.05 pg/ml (median) was 27% (OR = 0.27,95% CI: 0.09,0.79) of those with CD8>6.05 pg/ml. Here, CD4 is linked to cervical squamous intraepithelial neoplasia.