STX2 and hemolytic-uremic syndrome: More recently, Espadinha et al. (94) performed a PWAS of 531 STEC isolates, identifying associations between the development of HUS and the presence of stx2a, stx1a + stx2a, or stx1a + stx2c, as well as the co-occurrence of genes such as ygiW (stress-induced protein) with group_5720 (transcriptional regulation) and pfkA (6-phosphofructokinase-1) with fieF (Zn2+/Fe2+/Cd2+ efflux transporter), among other epidemiological factors.