Samples were then analyzed using SiMBiT, focusing on three parameters: KRASG12D mutation, the protein MUC1, which is associated with pancreatobiliary IPMN (the most aggressive IPMN subtype) and invasive cancer,9 and the protein CD55, a marker of HG-dysplasia in IPMN.10 This evidence concerns the gene MUC1 and pancreatic intraductal papillary-mucinous neoplasm.