In the 61 cyst fluids (Figure 1C, Supplementary Data), SiMBiT misclassified only three cases: one low-grade (LG)-IPMN and one LG-MCN were identified as nonmucinous cysts (false negative), and an abscess membrane was classified as LG-mucin-producing neoplasm (false positive). The gene discussed is MUC5AC; the disease is cyst.