CD40LG and neoplasm: Given the unavoidable adsorption of IgM onto FA-sLip in vivo and IgM’s diverse roles in immune responses, we proposed a natural IgM-hitchhiking delivery strategy to co-deliver tumor antigens and adjuvants to splenic marginal zone B cells, eliciting lasting antigen-specific antibodies production and cytotoxic T lymphocyte responses in vivo for effective tumor immunotherapy [206].