Moreover,Y-320 has also been reported to be able to enhance the sensitivityof multidrug-resistant tumor cells to lower doses of cytotoxic agents,including paclitaxel, vinorelbine, and doxorubicin. This chemosensitizing effect may also be attributed toits regulation of sialylation, as studies have shown that knockdownof ST6Gal1, a key sialyltransferase, could enhance sensitivity togemcitabine, a frontline treatment for pancreatic cancer. Besides, previous study has identified Y-320as a potent enhancer of premature termination codons (PTC) readthrough. This evidence concerns the gene ST6GAL1 and familial pancreatic carcinoma.