CD8A and neoplasm: The results showed that the depletionof CD8+ T cells nearly completely abrogated the antitumorefficacy of Y-320, underscoring the critical role of CD8+ T cells in Y-320-mediated tumor-targeted desialylation (Figure I–K), consistentwith prior studies. Besides, macrophagedepletion attenuated Y-320 therapeutic effect, indicating that macrophagescould also be essential (Figure I–K).