Further, to identifythe specific immune cells contributing toY-320-mediated tumor control, we selectively depleted key immune cellpopulationsCD4+ T cells, CD8+ T cells,NK cells, and macrophagesin CT26 tumor-bearing mice usinganti-CD4 antibodies, anti-CD8 antibodies, anti-Asialo-GM1 antibodies,and clodronate liposomes, respectively (Figure I–K). The gene discussed is CD4; the disease is neoplasm.