Further, while dysfunction in the endolysosomalsystem is well-recognized as being linked to PD, the high convergence between hits within our cell screeningdata and known genetic risk factors for PD indicate that GCase isparticularly sensitive to perturbations in the lysosomal environment.This suggests that upstream perturbationsboth genetic andenvironmentalmay converge on GCase to impair its activity.Interestingly, the penetrance of PD among carriers of GBA1 mutations is modest, suggesting that these mutations alone may notbe sufficient to cause PD. Here, GBA1 is linked to Parkinson disease.