In an LPS sepsis model utilizing THP-1 cells as a monocyte surrogate, we demonstrated that minocycline dose-dependently inhibited the production of inflammatory cytokines such as TNF-α, interleukin (IL)-6, and IFN-γ, as well as chemokines including IL-8 and interferon-inducible protein (IP)-10 (Tai et al., 2013). The gene discussed is TNF; the disease is Sepsis.