Building on this approach, we conducted a systematic druggable genome-wide MR analysis and identified 15 druggable genes significantly associated with PBC, including TYMP, MINK1, IL7, ADORA2A, CCR8, AP2M1, GDF11, MYC, NRBP1, GPI, MAP3K8, KCNJ11, BAHD1, ACTG1, and HLA-H. This evidence concerns the gene HLA-H and primary biliary cholangitis.