TYMP, linked to apoptosis and inflammation, is downregulated in non-alcoholic fatty liver disease(NAFLD) and modulates the NF-κB pathway in acute liver injury models (Gautheron et al., 2022; Hou et al., 2022; Higashikawa et al., 2020), suggesting a protective role in PBC. This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.