In PCOS rats, CGA improves follicular development, hormone levels, and oxidative stress in addition to reducing the clinical symptoms of PCOS via modifying the hypoxia-inducible factor 1α (HIF-1α) signaling pathway, suggesting that it may be used as a treatment for PCOS (Zhang et al., 2023b). The gene discussed is HIF1A; the disease is polycystic ovary syndrome.