When comparing the preoperative and the postoperative serum levels of a variety of biomarkers in one cohort study, IL-6, an acute phase inflammatory marker, was dramatically increased in patients with drug-resistant TN at 2 days after MVD (p = 0.013), and holding a trend toward increase in those after PBC (p = 0.069) (66), indicating that a greater surgical trauma related to the craniotomy procedure of MVD may sustain a stressful condition for the organism that responds by implementing the mechanisms of inflammation (67). The gene discussed is IL6; the disease is primary biliary cholangitis.