This MR study suggests that genetic variations in NCF1, ATRN, PIANP, CD48, GABARAPL2, MAP1LC3B, ARF3, KIR2DL5A, DLK1, COLEC12, GPI, SEMG2, and EIF4B are causally associated with postherpetic neuralgia (PHN). Here, EIF4B is linked to postherpetic neuralgia.