Liposome-based mRNA vaccines for COVID-19 significantly impact the innate immune response through the activation of pattern recognition receptors, such as TLRs, melanoma differentiation-associated gene 5 (MDA5), and NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) (Newton and Dixit 2012; Takeuchi and Akira 2010). This evidence concerns the gene IFIH1 and COVID-19.