2024) has confirmed that phillyrin can induce cell autophagy, thereby treating nasopharyngeal carcinoma (Wang et al. 2019), suggesting its potential antitumor effects. Research indicates that in colorectal cancer, disruption of the mucosal barrier results in the translocation of pro‐inflammatory mediators, which triggers the activation of the interleukin (IL)‐23–IL‐17A signaling pathway. The increased cytokines induced often indicate a poor prognosis (Tosolini et al. 2011). Here, IL17A is linked to colorectal cancer.