AKT1 and colorectal cancer: We conducted Western blot analysis to examine the effects of phillyrin on the PI3K/AKT signaling pathway in colorectal cancer cells by assessing the levels of PI3K, p‐PI3K, AKT, p‐AKT, mTOR, and p‐mTOR, along with their downstream targets, in HT29 and HCT116 cells.