This highlights the need to optimize the clinical management of fetal cardiac tumors: upon prenatal ultrasound detection of cardiac rhabdomyoma, amniocentesis should be performed promptly to analyze TSC1/TSC2 genes, and fetal cranial MRI should be recommended to screen for cortical tubers or subependymal giant cell astrocytomas (SEGAs) (13). Here, TSC2 is linked to astrocytoma (excluding glioblastoma).