EDNRB and Werner syndrome: Recent studies have identified multiple genetic loci linked with WS, including paired box 3 (PAX3), microphthalmia-associated transcription factor (MITF), the SRY-box transcription factor 10 (SOX10), endothelin 3 (EDN3), endothelin receptor type B (EDNRB), KIT ligand (KITLG), and snail family transcriptional repressor 2 (SNAI2).