This study investigates the diagnostic accuracy of five inflammatory biomarkers – delta neutrophil index (DNI); C-reactive protein/albumin ratio (CAR); procalcitonin (PCT); immature granulocytes count (IGc); and hemoglobin, albumin, lymphocyte, platelet score (HALPs) – in detecting acute appendicitis (AA) and identifying the most reliable marker for distinguishing complicated from non-complicated cases. Here, CALCA is linked to appendicitis.