Previous experimental studies have shown that the mTOR inhibitor, and EVR analogue rapamycin can induce neuropsychological changes, such as anxiety and depression, in healthy rodents (Bosche et al., 2015; Hadamitzky et al., 2014, 2018; Russo et al., 2013; Tsai et al., 2013; Yu et al., 2013). The gene discussed is MTOR; the disease is major depressive disorder.