MTOR and Anxiety: For example, experimental data demonstrated that immunosuppressive drugs, such as the mechanistic target of rapamycin (mTOR) inhibitor rapamycin, can cause anxiety- and depressive-like behaviors in rodents (Hadamitzky et al., 2014, 2018; Russo et al., 2013; Tsai et al., 2013; Yu et al., 2013).