Moreover, multiple tumor cells, including OS, can produce RANK, leading to an increase in RANKL expression (Kukita and Kukita, 2013; Tan et al., 2011) and changes in the metabolic regulator MAPK expression and mitochondrial homeostasis of tumor cells (Yuan et al., 2020; Rao et al., 2017). Here, TNFRSF11A is linked to neoplasm.